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KMID : 0356920100590010013
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Korean Journal of Anesthesiology
2010 Volume.59 No. 1 p.13 ~ p.16
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Effect of pretreatment with acetaminophen on withdrawal movements associated with injection of rocuronium: a prospective, randomized, double-blind, placebo controlled study
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Jeon Young-Hoon
Baek Sung-Uk
Park Sung-Sik
Kim Si-Oh
Baek Woon-Yi
Yeo Jin-Seok
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Abstract
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Background: Withdrawal movement during rocuronium injection is a common, unresolved adverse effect. We aimed to investigate the effect of IV acetaminophen pretreatment on withdrawal movement during rocuronium injection.
Methods: This study enrolled 120 American Society of Anesthesiologists (ASA) I-II patients undergoing general anesthesia. They were randomly assigned to three treatment groups. After occluding venous drainage using a tourniquet on the upper arm, the saline group received 5 ml of 0.9% sodium chloride solution, the lidocaine group received 40 mg of lidocaine, and the acetaminophen group received 50 mg of acetaminophen. During injection of pretreatment drug, pain was assessed on a four-point scale. The tourniquet was released after 120 seconds and anesthesia was performed using thiopental sodium 5 mg/kg followed by rocuronium 0.6 mg/kg. The withdrawal movement was graded on a four-point scale in a double-blind manner.
Results: The incidence of pain on pretreatment injection in saline, lidocaine, and acetaminophen groups was 7.7%, 5.1%, and 2.5%, respectively. The incidence of withdrawal movements was 77.5% in saline group, 32.5% in lidocaine group, and 37.5% in acetaminophen group (P < 0.05).
Conclusions: Acetaminophen and lidocaine reduced the incidence of withdrawal movement after rocuronium injection compared with saline.
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KEYWORD
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Acetaminophen, Injection, Lidocaine, Rocuronium, Withdrawal movement
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